Nosebleeds in advanced liver cancer are usually more dangerous if they are triggered by liver disease. Generally speaking, if patients with advanced stage of liver cancer who have spontaneous nosebleed and the symptoms are difficult to get better. It may be due to the fact that the patient is in a state of long-term liver function damage and then develops into serious liver function failure, which leads to a sharp decline in the patient’s coagulation function and induces symptoms such as nosebleed. If it is caused by liver failure, it is usually difficult to get better, and in serious cases, symptoms such as hemorrhage and hypovolemic shock may even occur. Therefore, there is a high risk of nosebleed if it is caused by this reason. However, if nosebleed is caused by the patient’s own deviated nasal septum, fragile nasal mucous membrane, trauma and bump, it is not serious. To sum up, if patients with advanced liver cancer have serious or persistent symptoms of nosebleed, they should go to the hospital in time to avoid delaying their condition.