The starting dose of metformin is 1 tablet twice daily. It is not exact to determine whether it is serious from two capsules of metformin in the morning and two capsules in the evening alone; it should be judged in combination with glycated hemoglobin, blood glucose level, and the presence of complications. If glycated hemoglobin, blood sugar, etc. exceeds the diabetes control target and there are complications, it may be more serious. Metformin is the basic medication in the treatment of type 2 diabetes mellitus, and if there are no contraindications, metformin is recommended to be kept in the treatment regimen. Metformin is contraindicated in cases of severe renal insufficiency, prodromal diabetic coma, severe infections and trauma. To minimize the gastrointestinal reaction to metformin, it is often started at a small dose and then gradually increased. Glycated hemoglobin needs to be controlled below 7% in diabetic patients; elevation indicates poor level of glycemic control in the last 2-3 months. Blood glucose is generally required to be controlled between 4.4 and 7.0 mmol/L in fasting and less than 10 mmol/L 2 hours after meals. Poor glycemic control in diabetes can lead to a variety of acute and chronic complications, such as diabetic ketoacidosis, diabetic peripheral neuropathy, diabetic retinopathy, diabetic nephropathy and so on. Therefore, whether two capsules of metformin in the morning and two capsules of metformin in the evening is serious still need to be judged by the doctor according to the glycated hemoglobin level, blood glucose level, the presence of complications and other comprehensive judgment. When you find high blood glucose, consult a doctor in time.