Symptoms of drug rash mostly include localized rash and systemic symptoms such as itching, high fever, diarrhea and enlarged lymph nodes. 1. local rash: different types of drug rash specific manifestations are different, generally manifested as bright red or purple papules, maculopapular rash, edema-like red patches, blisters, subcutaneous bruises, and other rash manifestations, the severe cases will cause oral cavity, eyelids, and other places of the mucous membrane damage, the local rash will be left behind after the local hyperpigmentation. 2. Systemic symptoms: some patients will be accompanied by obvious skin itching, for patients with severe drug rash, can be combined with high fever, chills, lymph node swelling and other manifestations; at the same time, due to local skin damage, easy to combine with bacterial, candida infection. For patients with drug rash, it is recommended that they go to the dermatology department of a regular hospital, under the guidance of a doctor to actively treat the disease, so as to avoid aggravation or recurrence.