When psoriasis is treated with biological agents, the length of time the medication is taken depends on the severity of the patient’s condition and affordability. If the condition is under control then there is no lifelong use, on the contrary, lifelong use is required. Psoriasis, commonly known as psoriasis, the exact cause of the disease is not yet completely clear, the condition is stubborn, can not yet be cured, after active treatment can control the progress of the disease, to achieve clinical cure. Biological agents are mainly used for psoriasis patients who have failed traditional drug treatment and cannot tolerate it. If the patient’s condition is well controlled after using biological agents, he/she does not need lifelong medication; if the condition is poorly controlled, he/she may need lifelong medication. Currently, biological agents used in the treatment of psoriasis include etanercept, infliximab, adalimumab, tofacitinib, etc., which should be used under the guidance of medical professionals to avoid adverse reactions.