The antibiotic of choice for the treatment of tetanus is penicillin. Tetanus is usually caused by infection with Clostridium tetani, an anaerobic bacterium that releases spasmodic toxins that cause muscle spasms such as difficulty in opening the mouth, neck stiffness, and corns, requiring prompt anti-infective treatment. Clostridium tetani is resistant to several antibiotics. Upon comparison, penicillin has a better antibacterial effect for Clostridium difficile infection, so penicillin is preferred for the treatment of tetanus, and can also be used in combination with metronidazole and streptomycin. Tetanus also requires the use of tetanus immunoglobulin, tetanus antitoxin and other drugs to neutralize the free toxin; the use of diazepam, phenobarbital, thiopental sodium and other such drugs to control and release the spasm; you can also use 10% chloral hydrate orally or by enema. Tetanus antitoxin should be routinely injected after injury to prevent tetanus infection. If there are early symptoms of tetanus such as bite muscle tension, patients are advised to go to the hospital in time. Medications should be applied under medical supervision.