A positive Hoffman’s sign means that the examination reveals hyperreflexia on that side of the tendon, which may be the result of cerebrovascular disease, cervical spine lesions, and other disorders. Hoffman’s sign, also known as the middle finger flick test, is a commonly used form of physical examination. A positive Hoffman’s sign means that after holding the joints of the index and middle fingers of the patient, letting the wrist joint dorsiflexion, and then quickly flicking and scraping the nail of the middle finger after the other fingers show a motor response, then it means that the tendon reflexes of that side are hyperactive, suggesting that the cone-bundle sign of the upper limb, indicating that there may be localized injury or lesions of the brain. Usually, if unilateral Hoffman’s sign is positive, it should be considered to be caused by diseases, which are mostly seen in cerebrovascular diseases, cervical spine lesions and other diseases. However, if the Hoffman’s sign is positive bilaterally and the patient has no other neurological signs, the clinical significance is not significant and there is no need to worry too much. To summarize, it is recommended that patients with positive Hoffman’s sign should under the guidance of the doctor do further relevant examinations, and cooperate with the doctor to carry out standardized treatment after clarifying the specific causes of the disease.