(Disclaimer: This article is only for popular science purposes, in order to protect the privacy of patients, the following content of the relevant information has been processed) Abstract: This article refers to an elderly pregnant woman, the process of pregnancy on time for obstetric examination, 12 weeks early pregnancy ultrasound, NT results are not abnormal, chromosome examination in mid-pregnancy, non-invasive DNA test results suggest that: high risk of trisomy 21-trisomy, amniocentesis is recommended, the results diagnosed as trisomy 21-trisomy, hospitalized for induction of labor, and recovered well after induction of labor. The result was diagnosed as 21-trisomy syndrome, and the pregnant woman was hospitalized for induced abortion, and her body recovered well after induced abortion. Basic information] Female, 35 years old [Disease type] Down’s syndrome [Hospital] General Hospital of Heilongjiang Province Nongken General Administration [Time of consultation] April 2022 [Treatment plan] Amniocentesis [Treatment cycle] 5 days of hospitalization, outpatient follow-up [Effect of treatment] Diagnosis of Down’s syndrome was confirmed, and the body recovered well after termination of pregnancy. The patient complained that the pregnant woman had stopped menstruating for more than 4 months, and now she was 17 weeks old. When she took a pregnancy test, she checked the non-invasive DNA test, and the result suggested that the risk of Down’s syndrome had increased greatly, and she was told to undergo amniocentesis, and the result of the test was diagnosed as a duplication of chromosome 21 after 3 weeks, which is related to Down’s syndrome, and the pregnant woman decided to be induced to have an abortion with the knowledge of her condition. Second, the treatment of this pregnant woman before pregnancy regular menstruation, menopause more than 40 days found in utero early pregnancy, pregnancy line progesterone test, suggesting that the low progesterone, given the conventional fertility preservation treatment, pregnant women intermittent bleeding has been on fertility preservation treatment, pregnancy 12 weeks for NT examination, did not see any obvious abnormalities, mid-pregnancy, there is still a vaginal bleeding, bed rest, fertility preservation treatment. At the 17th week of pregnancy, non-invasive DNA test was performed, and the result suggested high risk of trisomy 21. The pregnant woman was anxious and asked me, “Doctor, can I still have this baby? What should I do? I patiently told and comforted the pregnant woman that she needed to undergo amniocentesis to find out if she had a Down’s baby. The result of the amniocentesis was: chromosome 21 is duplicated, and the duplication of this region is related to Down’s syndrome, which is diagnosed as a Down’s syndrome patient. The pregnant woman asked me: Doctor, there is something wrong with this baby, and I am quite worried now. Will I be able to have a baby next time? I said: first of all, this baby can’t be had, it’s understandable that you’re in a bad mood and have a hard time, but the problem still needs to be solved, and you need to be hospitalized for induced abortion, and the longer the time goes on, the more damage may be done to you. If you want to get pregnant again, you will need to undergo a pregnancy test and then consider getting pregnant again. This pregnant woman was finally hospitalized and chose to terminate her pregnancy. The pregnant woman was found to be at high risk of trisomy 21 during pregnancy, and then amniocentesis was performed after she was fully informed, and finally the pregnancy was terminated knowing that there was a problem with the child, and she was also very relieved to know that there was a possibility that she would give birth to a child with a problem if she did not undergo an obstetric examination, which would ultimately bring a burden to her family and affect her life. Five days after the termination of pregnancy was discharged from the hospital, this patient’s uterine recovery, mental status are showing good, outpatient follow-up showed a very good prognosis, no complications. Precautions We are glad that this pregnant woman recovered well after termination of pregnancy, but we still need to pay attention to the following points: 1, 6 months after induced abortion before considering pregnancy, the purpose is to allow the uterus to get better repair, to meet the arrival of the next child in good condition. 2, before pregnancy preparation, the patient should be prepared for pregnancy. 2.Pregnancy preparation examination should be carried out before pregnancy, detailed preparation examination can avoid many congenital diseases of the fetus. And before pregnancy, follow the doctor’s instructions to take oral folic acid for 3 months, can effectively prevent fetal neural tube malformation. 3, pay attention to rest, relax the mind, regular life, avoid bad habits, such as smoking, alcoholism, staying up late and so on. And strengthen nutrition. Balanced diet, eat more fruits and vegetables. V. Personal Insights 1, the age of pregnancy ≧ 35 years old that is, advanced maternal age, is a risk factor, to carry out pregnancy tests on time to avoid adverse events. Mothers of advanced maternal age are prone to various risks and complications, on-time pregnancy checkups during pregnancy, and may increase the number of pregnancy checkups if abnormalities occur. 2, vaginal bleeding symptoms in the early stages of pregnancy may be caused by low progesterone, to the middle and late to pay attention to, Down’s syndrome may also appear without obvious causes of vaginal bleeding, there may be late fetal movement, fetal movement, slow development of the limbs, wide spacing between the noses, the head is large and other manifestations. The pregnant woman had vaginal bleeding, persistent birth control, so especially for the elderly pregnant women, abnormalities need to be highly vigilant, timely consultation and examination, symptomatic treatment. 3, big month induced abortion for pregnant women is a very difficult process, in the process of treatment should be given correct and positive guidance, to avoid psychological and mental factors affecting life. 4, pregnancy test every time period content is different, so we should be on time pregnancy test, the pregnant woman 12 weeks pregnant check did not see obvious abnormalities, but 17 weeks pregnant check found that the problem, the two time to check the content is different, for the pregnancy test should pay great attention to, mainly to avoid the occurrence of birth defects.