The patient wakes up every night around two o’clock, belongs to the problem of sleep disorder, insomnia, the formation of the main reasons to consider the following aspects: 1, to consider may be related to the patient’s irregular life, sleep rhythm was changed, for example, the patient usually wakes up in the middle of the night always play cell phones, games or because of the nature of work, night shift shift is more frequent, it is easy to cause changes in the rhythm of biological clock. It is easy to cause the patient to always be awake at two o’clock at night; 2. The patient wakes up around two o’clock every night, which may be related to psychological factors. Patients who work during the day is more stressful, more nervous, resulting in depression or too much thought, can cause insomnia at night; 3, patients every night around two o’clock insomnia, may also be caused by some diseases, such as diabetes patients in the night when the hypoglycemia or asthma attacks at night.