Blood uric acid 450μmol/L is elevated uric acid, normal blood uric acid is 150~416μmol/L for men and 89~357μmol/L for women. Elevated uric acid can be improved by dietary management, lifestyle adjustment and other ways of improvement, and combined with medication if necessary, it is recommended to consult a doctor in time. 1. Dietary management: patients with hyperuricemia should avoid drinking fructose drinks and alcoholic beverages, avoid eating animal offal, seafood, broths and other high-purine foods, and use less stimulating seasonings in cooking, eat more vegetables, low-fat or skimmed milk and its products and eggs, and drink more than 2,000ml of water a day under the condition of normal heart and kidney function. 2. Lifestyle adjustment: obese or overweight patients should be under the guidance of the physician appropriate exercise, reasonable weight loss, regular review of blood uric acid concentration in the hospital, try to avoid the use of hydrochlorothiazide and other drugs that may cause elevated blood uric acid. 3. Drug therapy: For uric acid 450μmol / L and through dietary management and lifestyle adjustment can not reduce blood uric acid, need to follow the doctor’s instructions for drug therapy. It is recommended that patients with 450 μmol/L uric acid go to the rheumatology and immunology department of regular hospitals for detailed consultation.