The sequelae of syphilis mainly include nerve damage, cardiovascular damage, skin damage, nasal deformity, etc., which are mainly triggered by the third stage of syphilis. 1. Neurological damage: Syphilis spirochetes cause neurological damage, so-called neurological syphilis, which can appear paralytic dementia, optic nerve atrophy, spinal tuberculosis and so on, and these damages are irreversible, which seriously affects the patients’ quality of life. 2. Cardiovascular damage: syphilis can cause syphilitic cardiovascular disease if it infringes on the cardiovascular system, resulting in aortic valve atresia, aortitis, syphilitic aortic aneurysm, myocardial dendritic swelling and so on. 3. Skin damage: advanced syphilis can lead to skin gummosis, ulcers, and atrophic, permanent scarring of the skin. 4. Nasal deformity: patients with advanced syphilis can have a collapsed nose and saddle nose. It is recommended that syphilis patients face the problem squarely and actively go to the hospital for diagnosis and treatment to control the progress of the disease and avoid serious sequelae or complications.