Loratadine tablets and Irbesartan are best taken two hours apart. Loratadine tablets are mainly used for the relief of allergic rhinitis, chronic urticaria, itchy skin diseases, etc. The drug belongs to the more long-lasting and effective tricyclic antihistamines, is a selective peripheral H1 receptor antagonist, but after taking it, there is a possibility of gastric distension, constipation, vomiting, excessive sweating and other adverse reactions. It is prohibited for those who are allergic to this drug, pregnant and lactating women, and those with severe hepatic or renal insufficiency. Irbesartan is mainly used for the treatment of type 2 diabetic nephropathy and essential hypertension combined with hypertension. The drug belongs to a kind of angiotensin II receptor antagonist, but there will be dizziness, palpitations, diarrhea and other adverse reactions, allergic to this drug, pregnant and lactating women, severe liver and kidney insufficiency is prohibited. Because of the different pharmacological effects of the two drugs, it is best to take them separately. Specific medication conditions should follow the doctor’s instructions to take, to avoid blind use of medication to cause discomfort.