Coughing in the middle of the night should not be taken blindly, and the medication should be analyzed according to the disease. If the cough is caused by cold, acute trachea-bronchitis, etc., dextromethorphan and ambroxol hydrochloride can be taken as symptomatic treatment; if gastroesophageal reflux disease is caused by gastroesophageal reflux disease, proton pump inhibitors can be taken. 1. Cold and flu, acute trachea-bronchitis, etc.: It can lead to coughing in the middle of the night and may be accompanied by fever, nasal congestion, muscle aches and pains, etc. If sputum is not easily discharged, it can be treated with dextromethorphan. If the phlegm is not easily discharged, drugs such as bromhexine and aminobromine hydrochloride can be taken to relieve cough and resolve phlegm. If the cough is dry, cough suppressants such as dextromethorphan may be given. 2. Gastroesophageal Reflux Disease (GERD): Coughing in the middle of the night due to the reflux of gastric contents that irritates the throat during sleep, in which case it is not recommended to blindly use medication, but to adjust the height of the pillow and to take a seated position to alleviate the cough. After clarifying the cause of the cough, you can take omeprazole, lansoprazole, mosapride and other drugs to inhibit gastric acid secretion and increase gastric power. Coughing in the middle of the night may be caused by other reasons, and should be treated after the cause is clarified. The above medications should be taken under the supervision of a doctor.