The treatment of high reticulocyte percentage is usually drug treatment or surgical treatment, depending on the different causes of the disease, the common causes are hemolytic anemia, acute blood loss, iron deficiency anemia and megaloblastic anemia, etc., and most of the clinical treatments are drug treatment. 1. A high percentage of reticulocytes indicates that the bone marrow erythrocyte lineage is hyperplastic. 2. Hemolytic disease with active proliferation of bone marrow erythrocyte lineage, resulting in high reticulocyte percentage, need to treat the cause of hemolytic disease, such as transfusion-related acute hemolytic reaction, and timely methylprednisolone and other medications for targeted treatment, reticulocyte percentage will be high will improve the situation. 3. High reticulocyte percentage caused by acute blood loss, need to treat the cause of acute blood loss, such as emergency hemostasis, the high situation will improve. 4. Iron deficiency anemia or megaloblastic anemia, which results in an exuberant proliferation of the bone marrow erythrocyte lineage and a high reticulocyte percentage, requires iron supplementation (ferrous succinate) or folic acid and vitamin B12 supplementation. Overall, it is recommended to seek medical attention for a high reticulocyte percentage, followed by standardized treatment according to the different causes of the condition.