Taking amlodipine and irbesartan blood pressure is still high first of all to rule out the problem of patient compliance, pay attention to lifestyle adjustments, and at the same time consult the doctor for medication adjustment. Taking amlodipine and irbesartan blood pressure is still high, first of all, should pay attention to whether in accordance with the doctor’s instructions regular use of medication, should be done on time, according to the amount of medication, do not arbitrarily adjust the dosage, and daily regular measurement of blood pressure and record. Secondly, the basis of lowering blood pressure lies in the adjustment of lifestyle, poor lifestyle can also weaken the effect of drugs. Hypertensive patients should do a low-salt diet, daily salt intake of less than 6g, eat less squash, pickles; can supplement potassium salt, eat more fresh fruits and vegetables; reduce fat intake, cooking less cooking oil, eat less fat meat, animal offal. In addition, more exercise, quit smoking and limit alcohol. If the above methods have been done and the blood pressure monitoring results have been unsatisfactory after using the medication, it is recommended to visit the cardiology department. Depending on the situation, the doctor may change the medication, increase the dosage of the medication appropriately, or combine it with other medications such as the diuretic hydrochlorothiazide. The medication should be used under the supervision of a physician and in strict compliance with medical advice, and blood pressure should be monitored regularly.