Benzoxicillin has an antibacterial effect and is mainly used for the treatment of penicillinase-producing staphylococcal infectious diseases, and the dosage forms used in the clinic mainly include tablets, injections and capsules. Benzoxicillin is an acid- and penicillinase-resistant penicillin drug, which can exert good antibacterial activity against penicillinase-producing staphylococci; the drug can be used for the treatment of penicillinase-producing staphylococci infectious diseases, such as sepsis, pneumonia, endocarditis, etc.; it can also be used for the treatment of mixed infections caused by Streptococcus pyogenes or Pneumococcus pneumoniae, and penicillin-resistant staphylococci. Common adverse reactions caused by this drug are rash, and intravenous administration may cause nausea, vomiting, and elevated serum aminotransferases. The drug needs to be contraindicated in those who have a positive penicillin skin test or a history of drug allergy to penicillin. Penicillin skin test is required before the use of benzoxiline; people suffering from urticaria, asthma, eczema and other allergic diseases and liver disease need to use the drug with caution. It is important to regulate the use of benzoxiline in strict compliance with medical advice and not to abuse it.