Diffuse large cell B-cell lymphoma is medically called diffuse large B-cell lymphoma, and in the late stage, there are local symptoms, such as enlarged lymph nodes, and there may also be symptoms related to organ infiltration, such as respiratory system showing symptoms of dyspnea and so on, and it is not ruled out that there are systemic consumptive symptoms, such as night sweats, fatigue and so on. 1. Local symptoms: diffuse large B-cell lymphoma will usually cause local painless lymph node enlargement, and localized hard lumps will be fused into a mass, and this symptom will be aggravated in the late stage, and the enlarged lymph nodes will be increased and enlarged in size. 2. Symptoms of organ infiltration: diffuse large B-cell lymphoma grows inside organs, and usually shows organ-specific symptoms, such as growing in the lungs or respiratory tract, chest cavity and other parts of the body, which may easily show symptoms of dyspnea, chest tightness, chest pain and so on. 3. Systemic consumptive symptoms: diffuse large B-cell lymphoma in advanced stage may have systemic aggressive spread, when the cancer cells proliferate, it will cause damage to multiple organs and functions of the body, showing symptoms such as weakness, weight loss, night sweating and fever. Diffuse large B-cell lymphoma in advanced stage is more harmful, and it is necessary to cooperate with doctors to do treatment in time to slow down the development of the disease.