Low cranial pressure disease in medicine is called low cranial pressure syndrome, low cranial pressure syndrome does not have the best treatment, the patient can follow the doctor’s advice to use general treatment, drug therapy, interventional therapy, surgical treatment and other ways of treatment. 1. General treatment: It is recommended that patients keep quiet, drink more water, and can drink high salt beverages, which is conducive to the rise of intracranial pressure. Heavier patients can elevate the tail of the bed by 10°~30°. 2. Drug therapy: If patients have headache symptoms, they can be treated with continuous epidural infusion of saline or dextrose anhydride as prescribed by the doctor, which can promote the recovery of the volume of intracranial cerebrospinal fluid and alleviate the symptoms of headache. 3. Interventional therapy: If conservative treatment is not effective, patients can undergo interventional therapy, such as the use of fibrin glue in the cerebrospinal fluid leakage epidural repair. 4. Surgical treatment: If conservative treatment and interventional treatment are ineffective, and the exact location of cerebrospinal fluid leakage has been clarified by imaging examination, then autologous epidural blood patch and percutaneous fibrin glue placement surgery can be performed. Postoperative bed rest is required to promote wound healing. If low cranial pressure syndrome is diagnosed, it is recommended that patients follow the doctor’s instructions for regular treatment.