Thyroid nodule grade 5 is a grade under thyroid ultrasound. Thyroid nodule grade 5 is a higher likelihood of malignant nodule and requires prompt treatment. The TI-RADS classification of thyroid nodules is a grading method used in ultrasound examinations, in which grade 5 is a solid nodule with irregular morphology and unclear borders, which is highly suspicious of malignant nodules. For patients with grade 5 thyroid nodule, timely treatment is needed, fine needle aspiration biopsy can be taken, if the result of puncture is malignant, timely surgical resection of diseased tissues is needed, and regular monitoring of thyroid function, pay attention to rest and strengthen the nutrition, etc. After surgery, regular monitoring of thyroid function, attention to rest and strengthen the nutrition, etc. are also needed. If the result of the puncture is benign, the thyroid nodule is small and there is no pressure from the surrounding tissues, it can be followed up regularly for observation. Specific treatment measures need to be formulated by professional doctors after judging the condition.