In terms of methotrexate combined with leflunomide drug itself, the combined efficacy of the two drugs is better than that of a single drug, but due to individual differences, there may be differences in the efficacy of the combination of the two drugs. Methotrexate combined with leflunomide is the drug of choice for the treatment of arthritis. Methotrexate combined with leflunomide has been used for many years in rheumatic immune diseases, and has been proven to be effective and safe in a large number of clinical trials, as well as affordable, and is widely used in the treatment of rheumatoid arthritis and systemic lupus erythematosus. The use of the above drugs needs to be carried out under the supervision of a doctor. Methotrexate combined with Leflunomide has good immunosuppressive and anti-inflammatory effects, which can radically control disease progression and disease activity, reduce joint disability and improve prognosis in the treatment of rheumatoid arthritis patients. In terms of methotrexate combined with leflunomide, the combined efficacy of the two drugs is better than that of the single drug, but the efficacy of the combination of the two drugs may vary due to individual differences. For individual patients, methotrexate and leflunomide monotherapy may be more effective than the combination of the two drugs and have fewer side effects; however, there may be individual differences in the combination of the two drugs in order to control disease activity. Therefore, it is recommended that patients who need to use methotrexate and leflunomide should consult a medical professional and do not use them privately.