The symptoms of fever after HPV vaccination need to be treated according to the causes, as follows: 1. cold and flu: if you have a cold and fever, just drink water, rest and take anti-cold drugs; 2. side effects of drugs: side effects of drugs can also cause fever and headache similar to cold and flu, so patients need to differentiate from other viral colds, pay attention to rest, drink the right amount of water and take drugs for headache and sleep. Allergic reactions: some patients have allergic reactions, fever, rash and other symptoms, usually need to be observed, may suddenly aggravate, such as breathing difficulties need to go to the hospital for treatment. If it is only a rash and fever, the symptoms can be relieved naturally by paying attention to rest and drinking water; 4. Mental factors: Patients may be in a state of tension and anxiety, more anxious before the vaccination and suddenly relaxed after the end, and may have fever, which can usually be relieved without treatment.