There are many causes of cough, such as respiratory tract infection, asthma, gastroesophageal reflux disease, etc. Different treatments are chosen according to different causes, and most of them can be quickly suppressed by medication. 1. Respiratory tract infections: Bacterial or viral infections cause acute inflammation of the trachea-bronchial mucosa, leading to coughing. If the cough is severe and difficult to stop, you can use central cough suppressants, such as dextromethorphan, etc. In addition, depending on the type of infection, take antibiotics or antivirals, such as penicillin, ribavirin, etc. to treat the original disease. 2. Asthma: commonly induced by exposure to allergens. Due to airway hyperresponsiveness, it is difficult to stop coughing. It is recommended to use glucocorticosteroids with bronchodilators, such as budesonide formoterol, etc. Nebulized inhalation to inhibit airway inflammation, which can relieve coughing and treat the primary disease. 3. Gastroesophageal Reflux Disease (GERD): refers to the reflux of gastric acid and gastric contents, which irritates the esophagus and causes coughing symptoms. You can use drugs to inhibit gastric acid, such as omeprazole, etc.; gastric stimulants, such as domperidone, etc. to treat the primary disease, and the cough can be relieved. In conclusion, if you have a severe cough that is difficult to relieve, you should go to the hospital in time to get a clear diagnosis and treatment under the guidance of your doctor.