Cranial defects are a relatively common occurrence, and many people suffer from them for one reason or another. For example, many children end up with cranial defects because of naughty falls, traffic accidents, or craniotomies for their own craniocerebral disorders. Once the skull defect occurs, it will be very dangerous, will cause damage to the intracranial pressure intracranial environment, affecting the intracranial blood circulation, cerebrospinal fluid circulation and other vital activities, affecting the normal operation of the brain and nerve function, and may even pose a threat to life. Therefore, timely cranial bone repair is needed. So what is the latest cranial repair surgery for children? Cranial bone repair in children should pay close attention to the selection of repair materials, surgical operation and strict management in the perioperative period. At present, the ideal cranial bone repair material is polyether ether ketone PEEK material, which is a kind of special polymer material, its properties are very close to the autologous cranium, especially its histocompatibility is very good, and it is three-dimensional shaping through CT scanning, embedded repair, which can be accurately fitted to the bone window, and can be well adapted to the children’s cranial growth and development, non-rejection, non-infection, and do not affect the postoperative of various radiological examinations. Therefore, polyetheretherketone is the latest development trend of cranial bone repair materials. In addition to the repair material, the surgeon’s technical level and perioperative management are also very important. At present, our team has a unique advantage in cranial bone repair surgery. We have been engaged in neurosurgery for nearly 30 years, with rich experience and skillful techniques, a strong nursing team and a complete set of systematic perioperative management system. Moreover, the team took the lead in introducing advanced polyether ether ketone PEEK material as the cranial bone repair material and achieved good clinical results.