The cranium is an important part of the human skeleton, located above the crestal column, and consists of 23 flat and irregular bones of varying shapes and sizes, which are very precise and complex. The cranium plays an important role in protecting and supporting the brain and head and facial organs. However, in real life, there are various risk factors that threaten the safety of the skull, such as traffic accidents, production safety accidents, falling objects, cranio-cerebral surgery and so on, which may ultimately cause skull defects. Cranial defects are very dangerous. Lack of hard skull protection, the brain is more vulnerable to external direct injury; the lack of skull also makes the intracranial environment change, intracranial pressure instability, affecting the blood supply, cerebrospinal fluid circulation, etc., affecting the normal operation of the brain and nerve function; at the same time, the appearance of abnormalities caused by cranial defects, but also easy to the patient’s psychological pressure, leading to autism, inferiority complex, and even depression. Therefore, cranial bone repair should be carried out in time after the occurrence of cranial bone defects. Cranial bone repair surgery is a relatively routine surgery in neurosurgery, and the technology is relatively mature. The major influence on the effect of cranial bone repair is the choice of cranial bone repair material. The choice of good materials can not only achieve a good shape repair, but also can improve some of the nerve function, which is conducive to postoperative recovery and normal life in the future; while the use of improper materials, it may cause a lot of adverse reactions, causing not symptoms, and even suffer from lifelong. So what is the best material for cranial repair today? This is the new polyether ether ketone PEEK material, this material has excellent performance, and the autologous skull is basically equivalent to the biological compatibility, can be three-dimensional molding, perfect restoration of the shape of the skull, to achieve the ideal repair effect.