Stenosis of 80% in the middle anterior descending branch is generally more serious and may lead to angina pectoris or myocardial infarction, etc., and patients need to do further treatment in time. 80% stenosis of the middle anterior descending branch will have a greater impact on the blood supply area of the middle anterior descending branch, which will easily cause insufficient blood supply to the myocardium, and will easily lead to angina pectoris when the patient is tired or emotionally agitated. In addition, if the plaque at the stenosis ruptures, it is easy to secondary thrombosis, thus causing acute myocardial infarction. Treatment mainly includes surgical treatment and medication-assisted treatment. Surgical treatments include stenting and coronary artery bypass grafting, which aims to improve blood flow in the coronary arteries by unclogging the narrowed vessels. Long-term use of antiplatelet agents such as aspirin, lipid-lowering drugs such as atorvastatin, and other medications to prevent cardiovascular events is also required under the supervision of a physician. The presence of 80% stenosis in the middle anterior descending artery should be taken seriously, and prompt medical attention should be given to maintain the health of the cardiovascular system through scientific treatment under the guidance of a physician.