There is no such thing as the fastest and most effective way to lower blood pressure. Oral medications that lower blood pressure faster are mainly short-acting antihypertensive medications, which have a faster effect when sublingualized. Generally include calcium antagonists, beta-blockers, ACEI class. However, antihypertensive should not pursue the fastest, but should be under the guidance of the doctor to choose the appropriate drugs to smoothly control blood pressure. 1. Calcium antagonist: clinically used fast antihypertensive drugs are mostly nifedipine tablets, sublingual or oral, the antihypertensive effect is relatively rapid, and can play a significant role in lowering blood pressure in a short period of time. There are also nifedipine tablets, amlodipine tablets and so on. 2. β-blockers: such as metoprolol tartrate tablets, atenolol tablets, after taking can effectively slow down the heart rate, reduce blood pressure. 3. ACEI antihypertensive drugs: such as captopril tablets, can be taken orally or contained, the effect of lowering blood pressure is relatively fast. It is worth noting that blood pressure is lowered too quickly may lead to organ ischemia, the occurrence of cardiovascular and cerebrovascular diseases, for patients with hypertension or to recommend the use of long-acting antihypertensive drugs, antihypertensive effect is smooth, long-lasting, conducive to the control of blood pressure and prevention of cardiovascular and cerebrovascular diseases.