Severe sweaty hands can be treated with TCM diagnosis and treatment. Severe sweaty hands can be categorized into Yangming middle cold syndrome, Yangming dry solid syndrome, heart and kidney yin deficiency syndrome, and blood stasis and obstruction syndrome, which can be treated with Lizhong Tang combined with Liujunzi Tang, Da Chengqi Tang, Maiwei Dihuang Pill, and Gui Zhi Poria Pill, respectively. Yangming middle-cold syndrome: cold sweat of the hands with cold hands and feet, easy fatigue, poor appetite, etc., choose Lizhong Tang combined with Liu Jun Zi Tang plus subtractions. Yangming dry solid syndrome: hand sweat is hot and accompanied by irritable heat in the hands and feet (irritable and sultry), love of cold drinks, dry stools, etc. Choose Da Cheng Qi Tang. Da Cheng Qi Tang is contraindicated in pregnant women. Heart and Kidney Yin deficiency: sweaty palms with burning palms, forgetfulness and insomnia, etc. Choose Mai Wei Di Huang Wan. Blood stasis obstruction syndrome: sweaty hands with dry mouth and throat, body tingling, etc., mostly aggravated at night, choose Gui Zhi Fu Ling Wan. Adverse effects or contraindications of the above drugs are not clear. If the hand sweat is very serious, it is recommended to seek medical advice as soon as possible, by a professional doctor for further examination, do not blindly take medication on your own, so as not to delay the condition.