Teeth grinding occurs mostly at night during rest and is medically known as bruxism or nocturnal teeth grinding, which may be accompanied by symptoms of toothache. Treatments include medications such as anti-anxiety and depression medications, botulinum toxin medications, and deworming medications, in addition to psychotherapy. Teeth grinding disorder is a condition in which there is habitual grinding of teeth during sleep or unconscious grinding habit during waking hours, which is a non-physiologic tooth contact. Teeth grinding itself does not cause pain, but in more severe cases of teeth grinding, it may lead to tooth damage and possibly a toothache. 1. Medication: (1) Anti-anxiety depressants: e.g., diazepam may improve sleep and cause the chewing muscles to relax sufficiently during sleep to relieve the symptoms of teeth grinding. Amitriptyline can be used to improve nocturnal teeth grinding caused by drugs such as duloxetine. This drug can inhibit the rapid eye movement period in the sleep cycle, which can help to reduce the symptoms of teeth grinding that occur during this sleep cycle. (2) Botulinum toxin medication: Treatment with botulinum toxin can modulate dental and maxillofacial dyskinesia and muscle tone disorders. Local injection of botulinum toxin into the chewing muscles on both sides of patients with chronic teeth grinding can reduce muscle excitability, and patients begin to stop grinding their teeth after the injection, but may sometimes cause symptoms such as difficulty in swallowing. (3) Anthelmintics: sometimes parasitic diseases such as intestinal ascariasis can also cause teeth grinding symptoms, and can be treated with anthelmintics such as mebendazole and albendazole. (2) Psychological treatment: Help patients relieve the pressure in study and work, and plan their time reasonably. Let the patient keep a relaxed state before going to bed to reduce the occurrence of teeth grinding. Patients should follow the doctor’s instructions for treatment, do not blindly treat yourself, so as not to delay the condition or cause adverse reactions.