For many years, people have considered SLE as an incurable disease. In the past two decades, we have had better treatments, but they have not been well recognized, and the abuse of Chinese and Western drugs has occurred, resulting in many patients who could have been in complete remission delaying treatment and even endangering their lives. In fact, all these phenomena should become a thing of the past. It should be clear that SLE is a multifactorial systemic autoimmune disease, and standardized treatment is very important, and individualized treatment plans should be implemented according to the specific conditions of patients. Clinically, we have seen many patients with relapse or aggravation of the disease due to irregular treatment. For example, some patients rapidly reduce or stop the medication after the clinical symptoms improve, resulting in recurrence of the disease, or delay the disease because they believe in small advertisements and take prescriptions. These are some of the reasons for the difficulty in treating SLE. Adrenocorticosteroids are not needed by everyone Adrenocorticosteroids are one of the most commonly used drugs for SLE, but they are by no means needed by every patient, and not everyone needs the same dosage regimen. It is not correct to “talk about hormones” or to abuse them. In principle, hormones are only used for patients with systemic damage with moderate to severe lupus, and oral therapy is generally used. Before each reduction, note any new changes in fever, fatigue, rash, arthralgia, mouth ulcers, hair loss, etc. If the symptoms and each laboratory test are normal, the dose can be reduced. If a relapse is suspected, the dose reduction should be stopped or the hormone should be increased to the minimum effective dose. This process should be carried out under the guidance of a doctor and should not be stopped suddenly because sudden discontinuation of hormones may show signs of adrenocortical insufficiency and may lead to relapse of the disease. Long-term application of hormones should pay attention to their adverse effects, and timely administration of appropriate preventive measures and treatment can reduce the harm. Immunosuppressants are better in small doses Another important class of drugs for the treatment of SLE is immunosuppressants, such as cyclophosphamide and mycophenolate, which are mainly used in patients with obvious organ damage. For patients with severe disease, cyclophosphamide is the most clinically used, which was often administered orally in the past and gradually replaced by intravenous shock therapy due to the high incidence of adverse reactions such as hemorrhagic cystitis and tumors. The general usage is high-dose shock, once a month, and after six months, the dosing interval can be extended, and the total course of treatment depends on the condition. In recent years, many studies at home and abroad have shown that low-dose cyclophosphamide shock therapy for SLE is equally effective and has fewer adverse effects than high-dose shock therapy. Therefore, our recommended regimen is to apply 400 mg/dose intravenously once every 1 to 2 weeks, and extend the dosing interval after 3 months, and after the remission and stabilization of the disease, other immunosuppressive drugs such as azathioprine can be used orally for maintenance therapy. Adverse reactions can occur in some patients, but it is safe and effective for most patients, only that blood routine and liver function should be monitored regularly during the course of treatment, and medication should be adjusted timely under the guidance of physicians. Other immunosuppressants can also be considered for some SLE patients, but they should be applied under the guidance of a specialist according to the actual condition of the patient. In conclusion, the treatment of SLE is a long-term process. Patients should have confidence and patience, receive regular treatment in regular hospitals, follow medical advice, choose individualized programs that are effective and have few adverse reactions, and standardize medication, and most of them can get complete remission.