Hormone therapy for SLE has a long duration and care should be taken to protect the hypothalamic-pituitary-adrenal axis. It is recommended to avoid long-acting and ultra-long-acting hormones such as dexamethasone, which have a strong effect on the hypothalamic-pituitary-adrenal axis. Long-term or high-dose or irregular use of hormones can induce and aggravate infections, lead to osteoporosis and aseptic necrosis of the femoral head, peptic ulcers, neuropsychiatric disorders, hypertension, diabetes, hyperlipidemia, sodium retention, hypokalemia, glaucoma, Cushing’s syndrome and a series of other adverse reactions, and in severe cases, even lead to death of patients. Ma Wukai, Department of Rheumatology and Immunology, Second Affiliated Hospital of Guiyang Traditional Chinese Medicine The adverse effects of hormone application are related to its dose and course of treatment, which need to be regularly observed and evaluated to ensure the efficacy and safety, and to improve the survival rate and prognosis of SLE treatment.