Low endogenous creatinine clearance can be treated by giving detoxifying medications, while the cause of the disease must be addressed. Low endogenous creatinine clearance is also known as renal failure. The main manifestation of the patient is an elevated level of toxins, represented by creatinine and urea. At this time, the detoxification ability of the kidneys is reduced can use drugs to help detoxification, such as urinary toxicity clear granules, Haikun kidney hi capsule, renal health suppository and so on. Along with the above symptomatic treatment, we must look for the underlying cause and treat it from the etiology. Only by dealing with the cause can the kidney function deteriorate more slowly. For example, if it is caused by diabetes, blood sugar should be controlled, and if it is caused by hypertension, blood pressure should be controlled. If it is caused by lupus, hormones and immunosuppressants should be applied to treat it. You also need to avoid factors that aggravate kidney function, such as vomiting and diarrhea due to unclean diet, cold and fever due to lack of warmth, etc.