Low endogenous creatinine clearance indicates renal failure, which in most cases is caused by chronic diseases, such as diabetes, hypertension, and chronic nephritis. When patients suffer from chronic diseases, such as diabetes, hypertension, chronic nephritis, etc., as mentioned above. If the blood sugar or blood pressure is not well controlled, the kidneys will be damaged. After long-term damage, the kidneys will gradually become fibrotic, the function will gradually decline, and the detoxification ability will be affected. Creatinine is a kind of toxin, which is manifested by the decrease of creatinine clearance ability, and the main manifestation is the significant increase of creatinine when checking the kidney function. At this time, on the one hand, you can use some drugs to reduce creatinine, such as urinary toxin clear granules, medicinal charcoal tablets, Haikun Kidney Hi capsule, etc. On the other hand, we need to control the underlying disease, such as diabetes caused by the need to control blood sugar, hypertension caused by the need to control blood pressure and so on.