If only the blood creatinine is low, usually there is no special pathological significance in the clinic. Blood creatinine belongs to endogenous, its molecular weight is small, is able to be excreted through the urine, clinical often as an evaluation of renal function indicators is the value of blood creatinine level. Creatinine is a metabolic product of muscle tissue, so the muscle tissue content will make the base value of creatinine affected. Low creatinine is most common in the elderly or people who are bedridden or long-term vegetarians, as well as in thin children, malnourished people and people with wasting disease. When creatinine is low, it is important to increase the protein diet and focus on balanced nutrition. If only the blood creatinine is low, usually there is no special pathological significance in the clinic. If there are abnormalities in renal function, it is necessary to combine with other indicators such as urea nitrogen, blood cystatin C to evaluate renal function. If there are abnormalities in renal function, it is necessary to go to the hospital in a timely manner, follow the doctor’s instructions to further search for the cause, and standardize the treatment in a timely manner.