L-A s p is one of the main drugs used in the treatment of ALL and is of great significance for the long-term prognosis of the child. However, it has related side effects: 1, the more common ones are allergic reactions (such as rash, dyspnea, facial edema), liver damage, pancreatitis, loss of appetite, etc.; 2, the rare ones are hyperglycemia, hyperuricemia, hyperthermia, psychotoxicity and neurotoxicity, etc.; 3, the rare ones are hypofibrinogenemia, reduction of coagulation factors V and VIII, intracranial hemorrhage or thrombosis, lower limb venous thrombosis and bone marrow suppression, etc. There are also Hypervolemia, alopecia, etc. Precautions: 1. Menadione is an exogenous bacterial protein preparation with high immunogenicity, and repeated injections are prone to allergic reactions, so patients should be hospitalized to observe the condition for timely treatment. 2. Liver and kidney function, blood glucose, urine glucose and coagulation function should be tested during the drug administration, and any abnormality should be consulted immediately. 3.Strict control of the child’s diet and avoid overeating: (1) strict control period, 3 days before, during and 2 weeks after discontinuation of medication, during which light and easily digestible low-fat and low-sugar foods should be chosen; (2) transition period of diet quality, 2 to 4 weeks after discontinuation of medication, during which there is a gradual transition to a normal diet. 4.Keep the bowel movement smooth, once the child has abdominal pain, please consult the doctor in time. 5. Pay attention to the prevention of infection, avoid cold and unclean food, and avoid catching cold.