What kind of medicine is good for old hiccups should be given symptomatic treatment according to different causes. Firstly, hiccups caused by cold stomach or improper diet, as well as dyspepsia caused by certain diseases, resulting in slowing down of gastrointestinal peristalsis and gastric insufficiency of gastric motility, can be orally administered gastric stimulants, such as domperidone, moxapride, cisapride, etc., which can alleviate the symptoms of hiccups. Secondly, if the patient is accompanied by acid reflux, belching, heartburn and other symptoms, it may be hiccups caused by excessive gastric acid secretion, and proton pump inhibitors, such as omeprazole, pantoprazole, rabeprazole and so on, should be given. Then inflammation of gastric mucosa, such as gastritis caused by Helicobacter pylori infection, can also appear hiccups, then should be given anti-Helicobacter pylori quadruple therapy to eradicate Helicobacter pylori. If the symptoms of hiccups recurring should go to the hospital to do relevant examinations, such as gastroscopy, to clarify the cause of the disease under the guidance of the doctor to give the correct drug treatment.