Pharyngitis generally has no direct effect on total liver bilirubin. Liver disease is generally considered to be the cause of liver total bilirubin numbers. Pharyngitis is an inflammatory infection or injury to the mucosal surface of the pharynx, which usually causes coughing, sputum, sore throat, and other symptoms, and also leads to an increase in leukocytes in routine blood tests, but does not usually cause a change in the total bilirubin count. When the total bilirubin count in the liver increases or decreases, it is usually necessary to consider the presence of viral hepatitis, cirrhosis, liver injury or hemolytic anemia. Such diseases can directly affect liver function, resulting in changes in total bilirubin levels. In addition, a sudden increase in total bilirubin can be caused by drinking too much alcohol in a short period of time or by strenuous exercise, which is a physiologic phenomenon. After pharyngitis has developed, prompt medical attention is recommended. If there are abnormal changes in bilirubin in the liver, further liver function tests are recommended and can help confirm the diagnosis.