Bone metastasis is one of the common metastatic sites of cancer, and once metastasis occurs in many places at the same time, external radiotherapy is often unable to take care of it. Particle implantation is one of the minimally invasive treatments for tumors, which is gaining more and more attention due to its advantages of easy operation and high local control rate. The patient had multiple bone metastases of nasopharyngeal cancer, and rib metastasis was one of them, which could not be taken care of by external radiotherapy. After particle implantation, the tumor was completely inactivated in the local lesion.