The side effects are not very obvious with long-term use, but individuals may experience weight gain during long-term use, which can be controlled through proper diet control and physical exercise. Mafulon is very effective in regulating menstruation and contraception, and has no significant side effects, so long-term use is not a problem as long as weight is controlled. However, you can’t take it after 40 years old because it is a highly effective estrogen and progestin hormone compound. If you are older, have high blood pressure, diabetes or blood clots, and you have been smoking for a long time, you can’t take it because it may cause blood clots.