Nexium, also known as esomeprazole magnesium, can cause the following side effects with long-term use: i. Long-term use can Nexium increase the risk of osteoporosis and fracture, and low-dose, short-course treatment should be considered. Second, long-term use of Nexium can cause the occurrence of pneumonia. Third, long-term use of Nexium will cause intestinal infection, so that the pH in the stomach increases, the barrier function of gastric acid decreases, so that bacterial colonization in the stomach, intestinal flora overgrowth, so that the incidence of diarrhea increases in patients. Fourth, long-term use of this drug can also cause iron deficiency anemia. V. Long-term use of this drug will also cause vitamin B12 deficiency, the acidic environment in the stomach is an important condition for vitamin B12 absorption, long-term use of Nexium will inhibit stomach acid, which may affect the absorption of vitamin B12. Six, long-term use of nexium will also cause hypomagnesemia, especially while taking digoxin, or other drugs that may cause hypomagnesemia. Patients can consider before starting to take drugs, should be measured blood magnesium concentration, after the drug should also be measured blood magnesium concentration. Seven, long-term use of Nexium can also cause gastric fundic gland polyps, polyps can degenerate and disappear after stopping Nexium.