Hyperlipidemia is a comprehensive metabolic disease, which requires long-term medication treatment. The statins are the most commonly used lipid-lowering drugs, including simvastatin, pravastatin, lovastatin, atorvastatin, and rasulvastatin, etc. Long-term use can not only lower the blood lipid level, but also stabilize the potential foci of human blood vessels – atheromatous plaques (stable plaques), which can effectively reduce the incidence of cardiovascular and cerebrovascular diseases. But after all, there are certain risks associated with long-term medication. Therefore, when taking statins for a long time, it is necessary to pay attention to the following matters: First, pay attention to monitoring liver function, because statins are damaging to the liver, and most statins need to be metabolized by the liver, therefore, liver damage and elevated transaminases have become common side effects of oral statins. The purpose of monitoring lipids is to see if additional medication is needed to bring the lipid control up to standard. Among the heavier side effects of statins, rhabdomyolysis can be considered one. If you experience muscle pain, stiffness or spasm, or weakness after taking a statin orally, you should test your myocardial enzyme profile for possible rhabdomyolysis in addition to the regular physical examination. Fourth, pay attention to monitoring blood sugar, statins can also affect the metabolism of blood sugar, so during the use of drugs need to regularly monitor blood sugar. Fifth, pay attention to lifestyle, control diet, avoid eating more high-fat, greasy, high cholesterol food, control the intake of salt and sugar, and eat less stimulating food. Eat a light diet, preferably with vegetable oils, and eat more fruits and vegetables. Control the intake of calories and avoid overeating. Sixth, pay attention to the combination of medication. The combination of medication is an important risk factor for xerostomia damage caused by statins. In other words, when the body needs to take other drugs, it is necessary to tell the doctor about their own medication to avoid adverse effects in the combination of drugs, which can damage liver function. Seven, pay attention to the dosage of drugs, statins caused by the occurrence of liver damage and the dose has a certain relationship, generally taking a dose of 10-20 mg, generally does not cause an increase in transaminases, remember not to increase the dose without authorization. Eight, pay attention to take with water, during the drug should avoid a lot of grapefruit (grapefruit), orange peel, Buddha’s hand, white wine and other food, because such food can aggravate the adverse effects of statins. Nine, pay attention to exercise, proper exercise is also essential, do more aerobic exercise, avoid over-exercise. In addition, you should also develop good habits of not smoking or drinking, early to bed and early to rise.