The cure rate of acute megakaryocytic leukemia is not high, and some patients can achieve a state of remission through chemotherapy. Acute megakaryoblastic leukemia is a type of acute leukemia, which is relatively rare in clinic, and is dominated by ascites and enlarged lymph nodes. Patients with this type of leukemia usually show pallor, weakness, bleeding and anemia, and enlargement of liver, spleen and lymph nodes is less common. Acute megakaryocytic leukemia is currently treated with chemotherapy, targeted drug therapy, hematopoietic stem cell or bone marrow transplantation. The prognosis is determined by the combination of the patient’s age, physical fundamentals, and sensitivity to treatment, and some patients can achieve remission status through chemotherapy. Drugs include cytarabine, Zoerythromycin, and Vinacrine. Acute megakaryocytic leukemia should go to the regular hospital in time, by professional doctors according to the condition and the patient’s physical condition targeted to develop a treatment plan.