High-grade squamous intraepithelial lesions are a type of precancerous lesions. It is prone to malignant lesions if not treated properly, which can seriously affect the physical and mental health of patients. For high-grade squamous intraepithelial lesions, the treatment is based on conization surgery or Lipo knife surgery. If the symptoms have a tendency to worsen, further treatment needs to be considered. Although high-grade squamous intraepithelial lesions have the tendency of malignant lesions, the prognosis is relatively good, as long as the treatment measures are timely, generally will not endanger the patient’s life, so even if there are high-grade squamous intraepithelial lesions do not need to worry too much anxiety, maintain a good mood. However, the treatment should not be taken lightly, and an active treatment attitude should be adopted to find the predisposing factors.