The number of grains of colchicine per day needs to be based on the specific condition, due to different dosages for different conditions. Such as 0.5mg a piece, gout acute phase to reach the therapeutic amount generally need 3-5mg (6-10 tablets), 24h up to 6mg (12 tablets), stop taking 72h after a day amount of 0.5-1.5mg (1-3 tablets), a total of 7 days. Adverse effects of colchicine are mostly gastrointestinal reactions, such as nausea, vomiting, diarrhea, watery diarrhea and bloody dehydration in poisoning, and in severe cases, shock, bone marrow suppression, and cellular damage to the kidney, liver, circulation and central nervous system. It is contraindicated for those with low myeloproliferative, hepatic and renal insufficiency. Precautions: If vomiting, diarrhea and other reactions occur, the dosage should be reduced, and in serious cases, the drug should be stopped immediately. Use with caution in patients with bone marrow hematopoietic insufficiency, severe heart disease, renal insufficiency and gastrointestinal disorders. During the use of the drug should be regularly checked blood and liver and kidney function. Colchicine should be used under the supervision of a doctor.