Patients with pancreatic cancer do not necessarily have persistent pain. Pancreatic cancer is a kind of digestive malignant tumor with insidious onset, rapid progression, extremely poor treatment effect and prognosis, and its incidence rate is on the rise worldwide. The incidence of pancreatic cancer is increasing worldwide. Pancreatic cancer has an insidious onset, and early diagnosis is difficult, and most patients are already in the middle or late stage when they are diagnosed. Depending on the location and size of the tumor, the affected organs and its severity, pancreatic cancer patients may manifest epigastric or back pain, nausea, abdominal distension, jaundice, new-onset diabetes mellitus, weight loss and change of stool properties, etc. Occasionally, patients with acute pancreatitis as the main manifestation. In early stage patients, patients may present with no specific symptoms or only intermittent/persistent epigastric pain, back pain, gastrointestinal symptoms (loss of appetite, etc.), which may be vague, distended, or dull. In addition, the pain may also be associated with a change in body position. In intermediate to advanced pancreatic cancer, persistent, severe abdominal pain can occur when the tumor invades the abdominal nerves from. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for comprehensive assessment of the condition and follow the doctor’s instructions for treatment to avoid delay.