The causes of positive urine leukocytes are mainly urinary tract infection, interstitial nephritis, lupus nephritis and other causes. 1. Urinary tract infection: it is the most important cause of positive urine leukocytes, including pyelonephritis, cystitis, urethritis, etc. Patients often have symptoms such as fever, back pain, frequent urination, urgency, tingling at the urethral opening, etc. Bacterial growth can be seen in urine culture. 2. Interstitial nephritis: Drugs or infections can cause damage to the kidney interstitium. Patients may have positive urine leukocytes, and there may be decreased urine specific gravity and increased nocturia as clinical manifestations. 3. Lupus nephritis: some patients may have positive urine leukocytes, but it is relatively rare. Positive urine leukocytes may also have other reasons, such as drinking too little water, etc. It is recommended that patients with positive urine leukocytes consult the hospital in a timely manner, and complete the relevant examinations under the guidance of the doctor, such as the cause of the disease, it should be actively treated to avoid the development of the disease.