Small meatballs at the crown may be caused by pearly penile papules, condyloma acuminatum, syphilis and other diseases, which can be treated with medication, surgery, physiotherapy and other ways. 1. pearly penile papules: patients with pearly penile papules will have pimples on the coronal edge of the penis and the coronal groove, which is a benign lesion that usually does not have any uncomfortable feeling and does not require any treatment. 2. Condyloma acuminatum: Condyloma acuminatum patients will appear in the coronal groove of the soft texture of small particles, and accompanied by erosion, bleeding and other symptoms. Patients can follow the doctor’s instructions to use imiquimod cream, onychomycosis cream and other topical cream treatment, but also can use 5-fluorouracil injection, recombinant human interferon alpha 1b injection and other drugs treatment. Patients can also take physical therapy, such as cryotherapy, laser therapy, electrocautery treatment. 3. Syphilis: The main symptoms of syphilis are small red spots on the penis or glans, syphilis rash and so on. Patients can follow the doctor’s instructions to use injectable benzylpenicillin, injectable procaine penicillin and other penicillin treatment. To summarize, when patients have symptoms of small meat grain at the crown, they should consult a doctor in time, follow the doctor’s instructions for treatment, and avoid blindly using drugs.