Bone metastasis of prostate, i.e. prostate cancer combined with bone metastasis, will cause bone pain, bone fracture, lower limb pain and other symptoms, and even lead to lower limb paralysis. 1. Bone pain: when prostate cancer patients develop bone metastasis, the most common symptom is bone pain. When cancer cells invade bones, patients will feel obvious bone pain. 2. Fracture: Fracture is mainly pathological fracture, when prostate cancer patients have bone metastasis, the fracture with tumor metastasis will be worse than normal fracture strength, and if there is a slight external impact, patients may have fracture. 3. Lower limb pain: Lower limb pain is mainly due to the fact that bone metastasis of prostate cancer occurs in the spine, and if the patient’s lesion is large, it will compress the patient’s nerves, so there will be lower limb pain, fatigue, incontinence or even paralysis. When bone metastasis occurs in patients with prostate cancer, different symptoms can occur, depending on the site of metastasis and from person to person. It is recommended that patients go to the hospital for consultation in time and take specific treatment measures according to the doctor’s advice.