Proteinuria is a common clinical manifestation in patients with glomerulonephritis, and the main therapeutic drug is glucocorticoids. The time for glucocorticoids to take effect in patients is related to individual differences, the patient’s responsiveness to the drug, and the type of pathology. In general, most patients take effect within 8-12 weeks of hormone administration, while some patients and specific pathologies may require up to 16 weeks for the hormone to take effect. Patients who do not see any effect after 16 weeks are called hormone-resistant patients, and then they need to be treated with a combination of immunosuppressive drugs and hormone withdrawal. For patients who have an effect within the relevant time frame, glucocorticoids should be slowly reduced by 10% of the original dose over 2-3 weeks, and after the reduction to the minimum dose, low doses of hormones should be maintained for a long time to avoid relapse.