The most commonly used clinical method for urine protein quantification is the 24H urine protein quantification method. This means that 24 hours of urine is retained to measure its volume and one regular urine is retained. The mass is measured according to the density multiplied by the volume, which is the quantification of 24h urine protein. Clinically, a urine protein quantification greater than 3.5 g is called massive proteinuria. Massive proteinuria can be seen in conditions such as nephrotic syndrome and diabetic nephropathy. Firstly, nephrotic syndrome causes, active anti-immunotherapy is recommended, the most commonly used approaches are hormones, cyclophosphamide, tacrolimus, cyclosporine, etc. Secondly, large amount of proteinuria caused by diabetic nephropathy, it is recommended to apply ACEI or ARB drugs, as well as actively controlling blood sugar and applying kidney-protective drugs, etc.