Neutrophil deficiency is a group of syndromes due to a decrease in the absolute value of peripheral blood neutrophils, requiring treatment of etiology, prevention and treatment of infections, promotion of granulopoiesis, immunosuppression and other treatments.
1. Etiologic treatment: exposure to suspected drugs or other pathogenic factors should be stopped immediately. Those with secondary reduction should actively treat the primary disease, and the granulocytes can be normalized after the disease is relieved or controlled.
2. Prevention and treatment of infection: those with moderate neutropenia have increased risk of infection and should pay attention to prevention, such as reducing access to public places, maintaining hygiene, and removing chronic foci of infection; those with severe neutrophil deficiency should take sterile isolation measures. For those who are already infected, pathogenetic examination should be performed to clarify the type and site of infection, and then anti-bacterial, anti-fungal and anti-viral treatments should be applied, and immunoglobulin is helpful in the treatment of severe infections.
3. Promote granulocyte generation: injection of recombinant human granulocyte colony-stimulating factor and recombinant human granulocyte-macrophage colony-stimulating factor can promote the proliferation and release of neutrophils, and enhance their phagocytosis and bactericidal and chemotaxis functions.
4. Immunosuppressant: For autoimmune granulocytopenia and granulocyte deficiency caused by immune mechanism, glucocorticoid and other immunosuppressant treatment can be used.
Attention to the occurrence of this disease should be actively treated to avoid serious infections, the specific treatment and the use of related drugs need to be directed by a professional doctor.