Sudden toothache in the middle of the night may be due to tooth decay, or may be due to pulpitis or periapical inflammation. 1.Sudden toothache in the middle of the night, you can use sliced ginger and bite on the painful part of the tooth. The ginger will have some ingredients into the mouth, play a role of anti-inflammatory and sterilization, can temporarily relieve the tooth pain. 2, can contain a high concentration of pepper water, pepper water concentration can temporarily numb the feeling in the mouth, can also temporarily relieve the pain. If the effect of these two methods is not too big, and then you can take some drugs, such as metronidazole or pain medication ibuprofen, wait until the next day when the conditions for medical treatment must be timely to go to the hospital for treatment.